Removal of GABA(A) Receptor γ2 Subunits from Parvalbumin Neurons Causes Wide-Ranging Behavioral Alterations

We investigated the behavioral significance of fast synaptic inhibition by αβγ2-type GABA(A) receptors on parvalbumin (Pv) cells. The GABA(A) receptor γ2 subunit gene was selectively inactivated in Pv-positive neurons by Cre/loxP recombination. The resulting Pv-Δγ2 mice were relatively healthy in th...

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Main Authors: Leppä, Elli, Linden, Anni-Maija, Vekovischeva, Olga Y., Swinny, Jerome D., Rantanen, Ville, Toppila, Esko, Höger, Harald, Sieghart, Werner, Wulff, Peer, Wisden, William, Korpi, Esa R.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166293/
https://ncbi.nlm.nih.gov/pubmed/21912668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024159
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