Defective Hematopoietic Stem Cell and Lymphoid Progenitor Development in the Ts65Dn Mouse Model of Down Syndrome: Potential Role of Oxidative Stress

AIMS: Down Syndrome (DS), a genetic disease caused by a triplication of chromosome 21, is characterized by increased markers of oxidative stress. In addition to cognitive defects, patients with DS also display hematologic disorders and increased incidence of infections and leukemia. Using the Ts65Dn...

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Detalhes bibliográficos
Main Authors: Lorenzo, Laureanne Pilar E., Chen, Haiyan, Shatynski, Kristen E., Clark, Sarah, Yuan, Rong, Harrison, David E., Yarowsky, Paul J., Williams, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166202/
https://ncbi.nlm.nih.gov/pubmed/21504363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3798
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