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Perinatal Loss of Ts65Dn Down Syndrome Mice

Ts65Dn mice inherit a marker chromosome, T(17(16))65Dn, producing segmental trisomy for orthologs of about half of the genes on human chromosome 21. These mice display a number of phenotypes that are directly comparable to those in humans with trisomy 21 and are the most widely used animal model of...

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Main Authors: Roper, Randall J., St. John, Heidi K., Philip, Jessica, Lawler, Ann, Reeves, Roger H.
格式: Artigo
語言:Inglês
出版: Copyright © 2006 by the Genetics Society of America 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456171/
https://ncbi.nlm.nih.gov/pubmed/16172497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.050898
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