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LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function

We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mitochon...

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Detalhes bibliográficos
Main Authors: Holmstrom, Sam R., Deering, Tye, Swift, Galvin H., Poelwijk, Frank J., Mangelsdorf, David J., Kliewer, Steven A., MacDonald, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165932/
https://ncbi.nlm.nih.gov/pubmed/21852532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.16860911
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