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Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas
The mechanisms regulating pancreatic endocrine versus exocrine fate are not well defined. By analyzing the effects of Ptf1a partial loss of function, we uncovered novel roles for this transcription factor in determining pancreatic fates. In a newly identified hypomorphic ptf1a mutant, pancreatic cel...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2418581/ https://ncbi.nlm.nih.gov/pubmed/18519637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1663208 |
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