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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
SHIP is an inositol 5′ phosphatase that hydrolyzes the PI3′K product PI(3,4,5)P(3). We show that SHIP-deficient mice exhibit dramatic chronic hyperplasia of myeloid cells resulting in splenomegaly, lymphadenopathy, and myeloid infiltration of vital organs. Neutrophils and bone marrow-derived mast ce...
Bewaard in:
| Gepubliceerd in: | Genes Dev |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Cold Spring Harbor Laboratory Press
1999
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316591/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10197978/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.7.786 |
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