SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

SHIP is an inositol 5′ phosphatase that hydrolyzes the PI3′K product PI(3,4,5)P(3). We show that SHIP-deficient mice exhibit dramatic chronic hyperplasia of myeloid cells resulting in splenomegaly, lymphadenopathy, and myeloid infiltration of vital organs. Neutrophils and bone marrow-derived mast ce...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Liu, Qiurong, Sasaki, Takehiko, Kozieradzki, Ivona, Wakeham, Andrew, Itie, Annick, Dumont, Daniel J., Penninger, Josef M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316591/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10197978/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.7.786
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