SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

SHIP is an inositol 5′ phosphatase that hydrolyzes the PI3′K product PI(3,4,5)P(3). We show that SHIP-deficient mice exhibit dramatic chronic hyperplasia of myeloid cells resulting in splenomegaly, lymphadenopathy, and myeloid infiltration of vital organs. Neutrophils and bone marrow-derived mast ce...

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Autors principals: Liu, Qiurong, Sasaki, Takehiko, Kozieradzki, Ivona, Wakeham, Andrew, Itie, Annick, Dumont, Daniel J., Penninger, Josef M.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 1999
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC316591/
https://ncbi.nlm.nih.gov/pubmed/10197978
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