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The SLCO1B1 rs4149032 Polymorphism Is Highly Prevalent in South Africans and Is Associated with Reduced Rifampin Concentrations: Dosing Implications

Among patients with tuberculosis, rifampin plasma concentrations and sputum conversion rates have been reported to be lower in Africans. Rifampin is a substrate of P-glycoprotein (coded for by the ABCB1 gene) and organic anion-transporting polypeptide 1B1 (coded for by SLCO1B1). The objectives were...

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Hlavní autoři:	Chigutsa, Emmanuel, Visser, Marianne E., Swart, Elizabeth C., Denti, Paolo, Pushpakom, Sudeep, Egan, Deirdre, Holford, Nicholas H. G., Smith, Peter J., Maartens, Gary, Owen, Andrew, McIlleron, Helen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2011
Témata:	Pharmacology
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3165308/ https://ncbi.nlm.nih.gov/pubmed/21709081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01833-10
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The SLCO1B1 rs4149032 Polymorphism Is Highly Prevalent in South Africans and Is Associated with Reduced Rifampin Concentrations: Dosing Implications

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