Distant and New Mutations in CTX-M-1 β-Lactamase Affect Cefotaxime Hydrolysis

The CTX-M β-lactamases are an increasingly prevalent group of extended-spectrum β-lactamases (ESBL). Point mutations in CTX-M β-lactamases are considered critical for enhanced hydrolysis of cefotaxime. In order to clarify the structural determinants of the activity against cefotaxime in CTX-M β-lact...

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Autors principals: Pérez-Llarena, Francisco José, Kerff, Frédéric, Abián, Olga, Mallo, Susana, Fernández, María Carmen, Galleni, Moreno, Sancho, Javier, Bou, Germán
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165300/
https://ncbi.nlm.nih.gov/pubmed/21730121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00298-11
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