Characterization of the New AmpC β-Lactamase FOX-8 Reveals a Single Mutation, Phe313Leu, Located in the R2 Loop That Affects Ceftazidime Hydrolysis

A novel class C β-lactamase (FOX-8) was isolated from a clinical strain of Escherichia coli. The FOX-8 enzyme possessed a unique substitution (Phe313Leu) compared to FOX-3. Isogenic E. coli strains carrying FOX-8 showed an 8-fold reduction in resistance to ceftazidime relative to FOX-3. In a kinetic...

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Main Authors: Pérez-Llarena, Francisco José, Kerff, Frédéric, Zamorano, Laura, Fernández, María Carmen, Nuñez, Maria Luz, Miró, Elisenda, Oliver, Antonio, Navarro, Ferran, Bou, Germán
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811397/
https://ncbi.nlm.nih.gov/pubmed/23877692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00818-13
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