Sequence of the Gene Encoding a Plasmid-Mediated Cefotaxime-Hydrolyzing Class A β-Lactamase (CTX-M-4): Involvement of Serine 237 in Cephalosporin Hydrolysis

The sequence of the gene encoding a novel cefotaxime-hydrolyzing β-lactamase (CTX-M-4) was determined. It was located in a plasmid harbored by a Salmonella typhimurium strain. CTX-M-4 was similar to the plasmidic cefotaxime-hydrolyzing β-lactamases CTX-M-2 and Toho-1 and related to the chromosomal β...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Gazouli, Maria, Tzelepi, Eva, Sidorenko, Sergei V., Tzouvelekis, Leonidas S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105797/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9593162/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.5.1259
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