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Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis

A highly-enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful α, α-disubstituted butyrolactone products. This reaction is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enanti-oselective thiour...

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Autores principales: Birrell, James A., Desrosiers, Jean-Nicolas, Jacobsen, Eric N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164931/
https://ncbi.nlm.nih.gov/pubmed/21800916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205602j
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