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7-substituted pterins provide a new direction for ricin A chain inhibitors
Ricin is a potent toxin found in castor seeds. The A chain, RTA, enzymaticlly depurinates a specific adenosine in ribosomal RNA, inhibiting protein synthesis. Ricin is a known chemical weapons threat having no effective antidote. This makes the discovery of new inhibitors of great importance. We hav...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164896/ https://ncbi.nlm.nih.gov/pubmed/21641093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.05.025 |
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