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Optimized 5-Membered Heterocycle-Linked Pterins for the Inhibition of Ricin Toxin A
[Image: see text] The optimization of a series of pterin amides for use as Ricin Toxin A (RTA) inhibitors is reported. On the basis of crystallographic data of a previous furan-linked pterin, various expanded furans were synthesized, linked to the pterin, and tested for inhibition. Concurrently, het...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3462456/ https://ncbi.nlm.nih.gov/pubmed/23050058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300099t |
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