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Peptide-conjugated pterins as inhibitors of Ricin Toxin A

Several 7-peptide-substituted pterins were synthesized and tested as competitive active-site inhibitors of Ricin Toxin A (RTA). Focus began on dipeptide conjugates, and these results further guided the construction of several tripeptide conjugates. The binding of these compounds to RTA was studied v...

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Detalhes bibliográficos
Main Authors: Saito, Ryota, Pruet, Jeff M., Manzano, Lawrence A., Jasheway, Karl, Monzingo, Arthur F., Wiget, Paul A., Kamat, Ishan, Anslyn, Eric V., Robertus, Jon D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552522/
https://ncbi.nlm.nih.gov/pubmed/23214944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3016393
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