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Determination and stability of CP-31398 in plasma from experimental animals by LC-MS/MS

A sensitive and accurate approach for the determination of CP-31398 (N-{2-[(E)-2-(4-methoxy-phenyl)-vinyl]-quinazolin-4-yl}-N’,N’-dimethyl-propane-1,3-diamine hydrochloride) in rat and dog plasma by LC-MS/MS was validated to support pre-clinical toxicological and pharmacological studies. Based on th...

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Detalhes bibliográficos
Main Authors: Muzzio, Miguel, Huang, Zhihua, Johnson, William D., McCormick, David L., Kapetanovic, Izet M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164819/
https://ncbi.nlm.nih.gov/pubmed/21831553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2011.07.013
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