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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis

Bcl-2-family proteins are key regulators of the apoptotic response. Here, we demonstrate that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB. We show that bfl-1 gene expression is dependent on NF-κB activity and that it can substitute for NF-κB to suppress TNFα-i...

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Gorde:
Argitaratua izan da:Genes Dev
Egile Nagusiak: Zong, Wei-Xing, Edelstein, Leonard C., Chen, Cailin, Bash, Judy, Gélinas, Céline
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 1999
Gaiak:
Research Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316475/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10049353/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.4.382
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