Assessment of the Safety and Biodistribution of a Regulated AAV2 Gene Transfer Vector after Delivery to Murine Submandibular Glands

Clinical gene transfer holds promise for the treatment of many inherited and acquired disorders. A key consideration for all clinical gene transfer applications is the tight control of transgene expression. We have examined the safety and biodistribution of a serotype 2, recombinant adeno-associated...

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Autori principali: Zheng, Changyu, Voutetakis, Antonis, Goldstein, Benjamin, Afione, Sandra, Rivera, Victor M., Clackson, Tim, Wenk, Martin L., Boyle, Molly, Nyska, Abraham, Chiorini, John A., Vallant, Molly, Irwin, Richard D., Baum, Bruce J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
Risk Assessment
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164441/
https://ncbi.nlm.nih.gov/pubmed/21625005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr144
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