Overcoming cellular senescence in human cancer pathogenesis

Elevation of p16, the CDKN2/p16 tumor suppressor gene (TSG) product, occurs at senescence in normal human uroepithelial cells (HUC). Immortal HUCs and bladder cancer cell lines show either alteration of p16 or pRb, the product of the retinoblastoma (RB) TSG. In addition, many human cancers show p16...

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Bibliografski detalji
Glavni autori: Yeager, Thomas R., DeVries, Sandy, Jarrard, David F., Kao, Chinghai, Nakada, Stephen Y., Moon, Timothy D., Bruskewitz, Reginald, Stadler, Walter M., Meisner, Lorraine F., Gilchrist, Kennedy W., Newton, Michael A., Waldman, Frederic M., Reznikoff, Catherine A.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 1998
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC316442/
https://ncbi.nlm.nih.gov/pubmed/9436977
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