Overcoming cellular senescence in human cancer pathogenesis

Elevation of p16, the CDKN2/p16 tumor suppressor gene (TSG) product, occurs at senescence in normal human uroepithelial cells (HUC). Immortal HUCs and bladder cancer cell lines show either alteration of p16 or pRb, the product of the retinoblastoma (RB) TSG. In addition, many human cancers show p16...

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Bibliografiska uppgifter
Huvudupphovsmän: Yeager, Thomas R., DeVries, Sandy, Jarrard, David F., Kao, Chinghai, Nakada, Stephen Y., Moon, Timothy D., Bruskewitz, Reginald, Stadler, Walter M., Meisner, Lorraine F., Gilchrist, Kennedy W., Newton, Michael A., Waldman, Frederic M., Reznikoff, Catherine A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 1998
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC316442/
https://ncbi.nlm.nih.gov/pubmed/9436977
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