Overcoming cellular senescence in human cancer pathogenesis

Elevation of p16, the CDKN2/p16 tumor suppressor gene (TSG) product, occurs at senescence in normal human uroepithelial cells (HUC). Immortal HUCs and bladder cancer cell lines show either alteration of p16 or pRb, the product of the retinoblastoma (RB) TSG. In addition, many human cancers show p16...

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Bibliografiske detaljer
Main Authors: Yeager, Thomas R., DeVries, Sandy, Jarrard, David F., Kao, Chinghai, Nakada, Stephen Y., Moon, Timothy D., Bruskewitz, Reginald, Stadler, Walter M., Meisner, Lorraine F., Gilchrist, Kennedy W., Newton, Michael A., Waldman, Frederic M., Reznikoff, Catherine A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316442/
https://ncbi.nlm.nih.gov/pubmed/9436977
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