Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2

Genome stability of human embryonic stem cells (hESC) is an important issue because even minor genetic alterations can negatively impact cell functionality and safety. The incorrect repair of DNA double-stranded breaks (DSBs) is the ultimate cause of the formation of chromosomal aberrations. Using G...

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Hauptverfasser: Bogomazova, Alexandra N., Lagarkova, Maria A., Tskhovrebova, Leyla V., Shutova, Maria V., Kiselev, Sergey L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2011
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164367/
https://ncbi.nlm.nih.gov/pubmed/21685510
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