Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway

Lung squamous cell carcinoma (SqCC), the second most common subtype of lung cancer, is strongly associated with tobacco smoking and exhibits genomic instability. The cellular origins and molecular processes that contribute to SqCC formation are largely unexplored. Here we show that human basal stem...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Weeden, Clare E., Chen, Yunshun, Ma, Stephen B., Hu, Yifang, Ramm, Georg, Sutherland, Kate D., Smyth, Gordon K., Asselin-Labat, Marie-Liesse
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268430/
https://ncbi.nlm.nih.gov/pubmed/28125611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2000731
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