Quantifying Ligand Bias at Seven-Transmembrane Receptors

Seven transmembrane receptors (7TMRs), commonly referred to as G protein-coupled receptors, form a large part of the “druggable” genome. 7TMRs can signal through parallel pathways simultaneously, such as through heterotrimeric G proteins from different families, or, as more recently appreciated, thr...

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Main Authors: Rajagopal, Sudarshan, Ahn, Seungkirl, Rominger, David H., Gowen-MacDonald, William, Lam, Christopher M., DeWire, Scott M., Violin, Jonathan D., Lefkowitz, Robert J.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164332/
https://ncbi.nlm.nih.gov/pubmed/21610196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.072801
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