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A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein

The influenza A M2 protein exhibits inwardly rectifying, pH-activated proton transport that saturates at low pH. A comparison of high-resolution structures of the transmembrane domain at high and low pH suggests that pH-dependent conformational changes may facilitate proton conduction by alternately...

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Bibliografiska uppgifter
Huvudupphovsmän: Polishchuk, Alexei L., Lear, James D., Ma, Chunlong, Lamb, Robert A., Pinto, Lawrence H., DeGrado, William F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164293/
https://ncbi.nlm.nih.gov/pubmed/20968306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101229m
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