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The Interplay of Thermodynamic Stability, Functional Tuning, and Drug Resistance in the Evolution of the M2 Proton Channel From the Influenza A Virus
We explore the interplay between amino acid sequence, thermodynamic stability, and functional fitness in the M2 proton channel of influenza A virus. Electrophysiological measurements show that drug-resistant mutations have minimal effects on M2’s specific activity, and suggest that resistance is ach...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2594009/ https://ncbi.nlm.nih.gov/pubmed/18611380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.04.011 |
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