Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

Influenza A and B viruses contain proton-selective ion channels, A/M2 and BM2, respectively, and the A/M2 channel activity is inhibited by the drugs amantadine and its methyl derivative rimantadine. The structure of the pore-transmembrane domain has been determined by both x-ray crystallography [Sto...

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Bibliographic Details
Main Authors: Jing, Xianghong, Ma, Chunlong, Ohigashi, Yuki, Oliveira, Fernando A., Jardetzky, Theodore S., Pinto, Lawrence H., Lamb, Robert A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492755/
https://ncbi.nlm.nih.gov/pubmed/18669647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804958105
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