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Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel
Influenza A and B viruses contain proton-selective ion channels, A/M2 and BM2, respectively, and the A/M2 channel activity is inhibited by the drugs amantadine and its methyl derivative rimantadine. The structure of the pore-transmembrane domain has been determined by both x-ray crystallography [Sto...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2492755/ https://ncbi.nlm.nih.gov/pubmed/18669647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804958105 |
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