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The Interplay of Thermodynamic Stability, Functional Tuning, and Drug Resistance in the Evolution of the M2 Proton Channel From the Influenza A Virus

We explore the interplay between amino acid sequence, thermodynamic stability, and functional fitness in the M2 proton channel of influenza A virus. Electrophysiological measurements show that drug-resistant mutations have minimal effects on M2’s specific activity, and suggest that resistance is ach...

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Main Authors: Stouffer, Amanda L., Ma, Chunlong, Cristian, Lidia, Ohigashi, Yuki, Lamb, Robert A., Lear, James D., Pinto, Lawrence H., DeGrado, William F.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2594009/
https://ncbi.nlm.nih.gov/pubmed/18611380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.04.011
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