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Mutations in Drosophila DP and E2F distinguish G(1)–S progression from an associated transcriptional program
The E2F transcription factor, a heterodimer of E2F and DP subunits, is capable of driving the G(1)–S transition of the cell cycle. However, mice in which the E2F-1 gene had been disrupted developed tumors, suggesting a negative role for E2F in controlling cell proliferation in some tissues. The cons...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC316409/ https://ncbi.nlm.nih.gov/pubmed/9271122 |
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