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Mutations in Drosophila DP and E2F distinguish G(1)–S progression from an associated transcriptional program

The E2F transcription factor, a heterodimer of E2F and DP subunits, is capable of driving the G(1)–S transition of the cell cycle. However, mice in which the E2F-1 gene had been disrupted developed tumors, suggesting a negative role for E2F in controlling cell proliferation in some tissues. The cons...

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Bibliografiske detaljer
Main Authors: Royzman, Irena, Whittaker, Allyson J., Orr-Weaver, Terry L.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316409/
https://ncbi.nlm.nih.gov/pubmed/9271122
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