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A role for ATR in the DNA damage-induced phosphorylation of p53

Phosphorylation at Ser-15 may be a critical event in the up-regulation and functional activation of p53 during cellular stress. In this report we provide evidence that the ATM–Rad3-related protein ATR regulates phosphorylation of Ser-15 in DNA-damaged cells. Overexpression of catalytically inactive...

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Pubblicato in:Genes Dev
Autori principali: Tibbetts, Randal S., Brumbaugh, Kathryn M., Williams, Josie M., Sarkaria, Jann N., Cliby, William A., Shieh, Sheau-Yann, Taya, Yoichi, Prives, Carol, Abraham, Robert T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 1999
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316393/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925639/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.2.152
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