Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 Domain I

DNA mismatch repair (MMR) is a highly conserved mutation avoidance mechanism that corrects DNA polymerase misincorporation errors. In initial steps in MMR, Msh2-Msh6 binds mispairs and small insertion/deletion loops and Msh2-Msh3 binds larger insertion/deletion loops. The msh2Δ1 mutation, which dele...

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Bibliographic Details
Main Authors: Kumar, Charanya, Piacente, Sarah C., Sibert, Justin, Bukata, Andrew R., O’Connor, Jaime, Alani, Eric, Surtees, Jennifer A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163898/
https://ncbi.nlm.nih.gov/pubmed/21726567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.030
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