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Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control

Opposing activities of acetyltransferases and deacetylases help regulate energy balance. Mice heterozygous for the acetyltransferase CREB binding protein (CBP) are lean and insulin-sensitized but how CBP regulates energy homeostasis is unclear. In one model, the main CBP interaction with the glucago...

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Bibliografiske detaljer
Main Authors: Bedford, David C., Kasper, Lawryn H., Wang, Ruoning, Chang, Yunchao, Green, Douglas R., Brindle, Paul K.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163393/
https://ncbi.nlm.nih.gov/pubmed/21803292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.06.010
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