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Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of autosomal-dominant Parkinson’s disease (PD). The second known autosomal-dominant PD gene (SNCA) encodes α-synuclein, which is deposited in Lewy bodies, the neuropathological hallmark of PD. LRRK2 contains a kinase domai...

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Bibliografische gegevens
Hoofdauteurs: Carballo-Carbajal, Iria, Weber-Endress, Susanne, Rovelli, Giorgio, Chan, Diane, Wolozin, Benjamin, Klein, Christian L., Patenge, Nadja, Gasser, Thomas, Kahle, Philipp J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163153/
https://ncbi.nlm.nih.gov/pubmed/20074637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.01.006
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