Kinetic Discrimination in Recognition of DNA Quadruplex Targets by Guanine-Rich Heteroquadruplex-Forming PNA Probes

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for ta...

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Main Authors: Roy, Subhadeep, Zanotti, Kimberly J., Murphy, Connor T., Tanious, Farial A., Wilson, W. David, Ly, Danith H., Armitage, Bruce A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163151/
https://ncbi.nlm.nih.gov/pubmed/21717030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1cc12805a
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