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Noncovalent binding and fluorogenic response of cyanine dyes to DNA homoquadruplex and PNA-DNA heteroquadruplex structures

Two symmetrical cyanine dyes based on benzothiazole heterocycles and a trimethine bridge were found to bind to a parallel-stranded DNA guanine quadruplex based on the MYC oncogene promoter sequence with high nanomolar affinity and 1:1 stoichiometry. The dyes exhibited substantial fluorescence enhanc...

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Autori principali: Mohammed, Halimatu S, Delos Santos, Junriz O, Armitage, Bruce A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166489/
https://ncbi.nlm.nih.gov/pubmed/21912726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/adna.2.2.16339
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