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Loop and Backbone Modifications of PNA Improve G-Quadruplex Binding Selectivity
Targeting guanine (G) quadruplex structures is an exciting new strategy with potential for controlling gene expression and designing anticancer agents. Guanine-rich peptide nucleic acid (PNA) oligomers bind to homologous DNA and RNA to form hetero-G-quadruplexes but can also bind to complementary cy...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819988/ https://ncbi.nlm.nih.gov/pubmed/19947597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja907250j |
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