Loop and Backbone Modifications of PNA Improve G-Quadruplex Binding Selectivity

Targeting guanine (G) quadruplex structures is an exciting new strategy with potential for controlling gene expression and designing anticancer agents. Guanine-rich peptide nucleic acid (PNA) oligomers bind to homologous DNA and RNA to form hetero-G-quadruplexes but can also bind to complementary cy...

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Bibliographic Details
Main Authors: Lusvarghi, Sabrina, Murphy, Connor T., Roy, Subhadeep, Tanious, Farial A., Sacui, Iulia, Wilson, W. David, Ly, Danith H., Armitage, Bruce A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819988/
https://ncbi.nlm.nih.gov/pubmed/19947597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja907250j
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