Histone Deacetylase Inhibitor Belinostat Represses Survivin Expression through Reactivation of Transforming Growth Factor β (TGFβ) Receptor II Leading to Cancer Cell Death

Survivin is a cancer-associated gene that functions to promote cell survival, cell division, and angiogenesis and is a marker of poor prognosis. Histone deacetylase inhibitors induce apoptosis and re-expression of epigenetically silenced tumor suppressor genes in cancer cells. In association with in...

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Detalhes bibliográficos
Main Authors: Chowdhury, Sanjib, Howell, Gillian M., Teggart, Carol A., Chowdhury, Aparajita, Person, Jonathan J., Bowers, Dawn M., Brattain, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162453/
https://ncbi.nlm.nih.gov/pubmed/21757750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.212035
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