Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response

DNA damage response is an important surveillance mechanism used to maintain the integrity of the human genome in response to genotoxic stress. Histone variant H2AX is a critical sensor that undergoes phosphorylation at serine 139 upon genotoxic stress, which provides a docking site to recruit the me...

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Dettagli Bibliografici
Autori principali: Wu, Ching-Yuan, Kang, Hong-Yo, Yang, Wei-Lei, Wu, Juan, Jeong, Yun Seong, Wang, Jing, Chan, Chia-Hsin, Lee, Szu-Wei, Zhang, Xian, Lamothe, Betty, Campos, Alejandro D., Darnay, Bryant G., Lin, Hui-Kuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162441/
https://ncbi.nlm.nih.gov/pubmed/21690091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.257469
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