FTY720 (Gilenya) Phosphate Selectivity of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P(1)) G Protein-coupled Receptor Requires Motifs in Intracellular Loop 1 and Transmembrane Domain 2

FTY720 phosphate (FTY720P) is a high potency agonist for all the endothelial differentiation gene family sphingosine 1-phosphate (S1P) receptors except S1P receptor subtype 2 (S1P(2)). To map the distinguishing features of S1P(2) ligand recognition, we applied a computational modeling-guided mutagen...

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Detalhes bibliográficos
Main Authors: Valentine, William J., Godwin, Virginia I., Osborne, Daniel A., Liu, Jianxiong, Fujiwara, Yuko, Van Brocklyn, James, Bittman, Robert, Parrill, Abby L., Tigyi, Gabor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162411/
https://ncbi.nlm.nih.gov/pubmed/21719706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.263442
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