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SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis

G-CSF signals contribute to granulocyte lineage specification. We previously found that G-CSF induces SHP2 tyrosine phosphorylation and that chemical inhibition of SHP1/SHP2 reduces CFU-G and prevents G-CSF but not M-CSF activation of ERK. We now find that SHP2 shRNA knockdown in the 32Dcl3 granuloc...

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Detalhes bibliográficos
Main Authors: Zhang, Li, Friedman, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162355/
https://ncbi.nlm.nih.gov/pubmed/21725048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-331157
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