The resveratrol analogue, 2,3′,4,5′-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene–DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene

Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. We hypothesised that 2,3′,4,5′-tetramethoxystilbene (TMS), an analogue of resveratrol and a potent CYP1B1 inhibitor,...

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Detaylı Bibliyografya
Asıl Yazarlar: Einem Lindeman, Tracey, Poirier, Miriam C., Divi, Rao L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162036/
https://ncbi.nlm.nih.gov/pubmed/21669939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/ger024
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