Tailored ß-Cyclodextrin Blocks the Translocation Pores of Binary Exotoxins from C. Botulinum and C. Perfringens and Protects Cells from Intoxication

BACKGROUND: Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin are binary exotoxins, which ADP-ribosylate actin in the cytosol of mammalian cells and thereby destroy the cytoskeleton. C2 and iota toxin consists of two individual proteins, an enzymatic active (A-) component and a s...

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Hauptverfasser: Nestorovich, Ekaterina M., Karginov, Vladimir A., Popoff, Michel R., Bezrukov, Sergey M., Barth, Holger
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161792/
https://ncbi.nlm.nih.gov/pubmed/21887348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023927
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