Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4(+) T Cells

OBJECTIVE: To investigate autoantigens in β-cells, we have used a panel of pathogenic T-cell clones that were derived from the NOD mouse. Our particular focus in this study was on the identification of the target antigen for the highly diabetogenic T-cell clone BDC-5.2.9. RESEARCH DESIGN AND METHODS...

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Autori principali: Delong, Thomas, Baker, Rocky L., Reisdorph, Nichole, Reisdorph, Richard, Powell, Roger L., Armstrong, Michael, Barbour, Gene, Bradley, Brenda, Haskins, Kathryn
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2011
Soggetti:
Immunology and Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161333/
https://ncbi.nlm.nih.gov/pubmed/21734016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0288
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