Insulin Receptor Tyrosine Kinase Substrate Enhances Low Levels of MDM2-Mediated p53 Ubiquitination

The tumor suppressor p53 controls multiple cellular functions including DNA repair, cell cycle arrest and apoptosis. MDM2-mediated p53 ubiquitination affects both degradation and cytoplasmic localization of p53. Several cofactors are known to modulate MDM2-mediated p53 ubiquitination and proteasomal...

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Autori principali: Wang, Ke-Sheng, Chen, Gang, Shen, Hai-Lian, Li, Ting-Ting, Chen, Fei, Wang, Qin-Wan, Wang, Zhi-Qin, Han, Ze-Guang, Zhang, Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160901/
https://ncbi.nlm.nih.gov/pubmed/21887275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023571
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