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Regulation of the Mdm2–p53 pathway by the ubiquitin E3 ligase MARCH7

The tumor suppressor p53 plays a prominent role in the protection against cancer. The activity of p53 is mainly controlled by the ubiquitin E3 ligase Mdm2, which targets p53 for proteasomal degradation. However, the regulation of Mdm2 remains not well understood. Here, we show that MARCH7, a RING do...

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Podrobná bibliografie
Vydáno v:EMBO Rep
Hlavní autoři: Zhao, Kailiang, Yang, Yang, Zhang, Guang, Wang, Chenfeng, Wang, Decai, Wu, Mian, Mei, Yide
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797962/
https://ncbi.nlm.nih.gov/pubmed/29295817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744465
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