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Regulation of the Mdm2–p53 pathway by the ubiquitin E3 ligase MARCH7
The tumor suppressor p53 plays a prominent role in the protection against cancer. The activity of p53 is mainly controlled by the ubiquitin E3 ligase Mdm2, which targets p53 for proteasomal degradation. However, the regulation of Mdm2 remains not well understood. Here, we show that MARCH7, a RING do...
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| Publicado no: | EMBO Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5797962/ https://ncbi.nlm.nih.gov/pubmed/29295817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744465 |
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