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Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum
TorsinA is a membrane-associated enzyme in the endoplasmic reticulum (ER) lumen that is mutated in DYT1 dystonia. How it remains in the ER has been unclear. We report that a hydrophobic N-terminal domain (NTD) directs static retention of torsinA within the ER by excluding it from ER exit sites, as h...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160655/ https://ncbi.nlm.nih.gov/pubmed/21785409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.233 |
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