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Heparanase affects secretory granule homeostasis of mouse mast cells through degrading heparin

BACKGROUND: Heparanase degradation of heparan sulfate plays important roles in a number of pathological processes, including inflammation. In vitro experiments show that heparanase is capable of degrading heparin, a polysaccharide present in mast cells where it has a key role in promoting the storag...

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Detalhes bibliográficos
Main Authors: Wang, Bo, Jia, Juan, Zhang, Xiao, Zcharia, Eyal, Vlodavsky, Israel, Pejler, Gunnar, Li, Jin-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160500/
https://ncbi.nlm.nih.gov/pubmed/21575986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2011.04.011
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