A comparative study of Lrrk2 function in primary neuronal cultures

OBJECTIVE: To assess the contribution of wild-type, mutant and loss of leucine-rich repeat kinase 2 (LRRK2; Lrrk2) on dendritic neuronal arborization. BACKGROUND: LRRK2 mutations are recognized as the major genetic determinant of susceptibility to Parkinson’s disease for which a cellular assay of Lr...

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Main Authors: Dächsel, Justus C., Behrouz, Bahareh, Yue, Mei, Beevers, Joel E., Melrose, Heather L., Farrer, Matthew J.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159957/
https://ncbi.nlm.nih.gov/pubmed/20850369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.parkreldis.2010.08.018
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